In a recent paper, specialists reported a case study of a 68-year-old woman with lung cancer, being investigated for possible metastases in the adrenal gland. On the image reconstructed using 4 mm voxels, there was no enlargement of the gland on CT, and there was a slightly increased FDG uptake. This led the clinicians to consider the gland to be benign. On a retrospective image reconstruction using 2 mm voxels, there was a higher SUVmax and a higher contrast (despite increased noise). The gland appeared suspicious and more likely to be metastatic. A follow-up PET/CT scan two months later revealed an even higher SUVmax and an enlarged right adrenal gland.
*Koopman D, van Dalen J, Jager P. Improved detection of a metastatic adrenal gland using FDG-PET with small voxels. Tijdschrift vood Nucleaire Geneeskunde. 2014; 36(3): 1279