MRI serves as the current gold standard in tumor treatment response monitoring. However, prognostic information cannot be obtained until weeks after the initial treatment. It is crucial for radiologists to be able to differentiate recurrent tumors from treatment-induced changes such as radiation necrosis. This means there is a vital need for methods that can detect response to therapy at early follow-up times.
Through Philips 3D APT, the only molecular contrast for glioma tumor grading and treatment follow-up, radiologists can differentiate tumor progression from treatment effect. 3D APT uses the presence of endogenous cellular proteins to produce an MR signal that directly correlates with cell proliferation, a marker of tumor activity.